Situatie
You try to turn the core isolation settings on or off but for some reason are not able to and you see a message saying: These setting is managed by your organization. This message can appear can happen due to the antivirus software or other apps that have control of your device. Its mostly harmless but annoying to deal with.
Solutie
1.Click START and type REGEDT.EXE then press ENTER
2.Expand HKEY LOCAL MACHINE\SYSTEM\CurrentControlSet\Control\DeviceGuard\Scenarios\CredentialGuard
3.Double click on the ENABLED key and set it to 0
4.Reboot.
Problem should be solved.